Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis
نویسندگان
چکیده
منابع مشابه
Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis
OBJECTIVE To test whether inhibition of sclerostin by a targeted monoclonal antibody (Scl-Ab) protects from bone and cartilage damage in inflammatory arthritis. Sclerostin is a potent inhibitor of bone formation and may be responsible for the low level of bone repair in patients with rheumatoid arthritis. METHODS Human tumour necrosis factor transgenic mice (hTNFtg mice) developing inflammato...
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OBJECTIVE Bone loss in arthritis is a complex process characterized by bone erosions and periarticular and generalized bone loss. The antigen-induced arthritis (AIA) model is mainly used to study synovitis and joint destruction, including bone erosions; however, periarticular bone loss has been less extensively investigated. The objectives of this study were to characterize and establish AIA as...
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INTRODUCTION Patients with chronic inflammatory diseases have increased bone loss and bone fragility and are at increased risk of fracture. Although anti-resorptive drugs are effective in blocking inflammation-induced bone loss, they are less effective at rebuilding bone. We have previously shown that treatment with sclerostin antibody (Scl-AbI) builds bone and can prevent or restore bone loss ...
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متن کاملEffect of sclerostin neutralizing antibody on periarticular and systemic bone in a murine model of rheumatoid arthritis: a micro-CT study
Introduction: Patients with chronic inflammatory diseases have increased bone loss and bone fragility and are at increased risk of fracture. Although anti-resorptive drugs are effective in blocking inflammation-induced bone loss, they are less effective at rebuilding bone. We have previously shown that treatment with sclerostin antibody (Scl-AbI) builds bone and can prevent or restore bone loss...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2013
ISSN: 0003-4967,1468-2060
DOI: 10.1136/annrheumdis-2013-203345